Table 5.

Toxicological information of some compounds from the U.S. National Library of Medicine [126].

Compound	Toxicological Information
Diosgenin	Oral LD50 (rat) > 8 g/kg
	Intraperitoneal LD50 (rat) 4872 mg/kg
	Oral LD50 (mouse) > 8 g/kg
	Intraperitoneal LD50 (mouse) 3564 mg/kg
Dioscin	Subcutaneous LD50 (mouse) >300 mg/kg
	Oral TDLo (rat) 1050 mg/kg/1W (intermittent)
	Oral TDLo (mouse):400 mg/kg/10D (intermittent)
Tigogenin	Intraperitoneal LDLo (rat):10 mg/kg
Harmine	Intramuscular TDLo (man):3 mg/kg
	Intravenous LDLo (cat) 10 mg/kg
	Subcutaneous LDLo (frog) 300 mg/kg
	Subcutaneous LD50 (mouse) 243 mg/kg
	Intravenous LDLo (mouse) 50 mg/kg
	Subcutaneous LD50 (rat) 200 mg/kg
Harmane	Intraperitoneal LD50 (mouse) 50 mg/kg
	Interperitoneal TDLo (rat) 1 mg/kg
	Intraperitoneal LD50 (rabbit) 200 mg/kg
Harmaline	Subcutaneous LD50 (rat) 120 mg/kg
	Subcutaneous LD50 (mouse) 120 mg/kg
	Intraperitoneal TDLo (rat) 4 mg/kg
Norharmane	Oral TDLo (rat) 1050 mg/kg/6W (continuous)

LD50, median lethal dose; TDLo, lowest published toxic dose; LDLo, lowest lethal dose.