Figure 1.

The predominant mechanisms of immunotherapy resistance in solid tumors. Several potential tumor-related mechanisms have already been identified as resistance mechanism against immunotherapy. Tumor microenvironment through the complexity of its structure, autophagy–depended antigen presentation on MHC I/II of antigen-presenting cells (APCs), tumor mutation burden and genetic/epigenetic alteration, molecular mechanism such as mutation several genes are the main mechanism of resistance in solid tumors.