Table 3.
Comparison of the genotypic and allelic frequencies of variants between the HBOC and control groups by gene.
| Gene | Variant | HBOC Patients | Control | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype Frequency | MAF | Genotype Frequency | MAF | |||||||
| BCRA 1 | rs3092995 | C/C | C/G | G/G | G | C/C | C/G | G/G | G | |
| 82% | 0% | 18% | 18% | 76% | 8% | 16% | 20% | |||
| rs8176318 | C/C | C/T | T/T | T | C/C | C/T | T/T | T | ||
| 84% | 10% | 6% | 11% | 90% | 10% | 0% | 5% | |||
| rs111791349 | G/G | G/A | A/A | A | G/G | G/A | A/A | A | ||
| 68% | 12% | 20% | 26% | 76% | 18% | 6% | 15% | |||
| rs12516 | C/C | C/T | T/T | T | C/C | C/T | T/T | T | ||
| 82% | 4% | 14% | 16% | 84% | 16% | 0% | 8% | |||
| BCRA 2 | rs15869 | A/A | A/C | C/C | C | A/A | A/C | C/C | C | |
| 84% | 6% | 10% | 13% | 82% | 18% | 0% | 9% | |||
| rs7334543 | A/A | A/G | G/G | G | A/A | A/G | G/G | G | ||
| 94% | 0% | 6% | 6% | 94% | 0% | 6% | 6% | |||
| c.*457 | A/A | A/C | C/C | C | A/A | A/C | C/C | C | ||
| 66% | 12% | 22% | 28% | 68% | 30% | 2% | 17% | |||
| rs11571836 | A/A | A/G | G/G | G | A/A | A/G | G/G | G | ||
| 82% | 4% | 14% | 16% | 82% | 14% | 40% | 11% | |||
| rs75353978 ** | TT/TT | delTT | TT/TT | delTT | ||||||
| 32% | 68% | 32% | 92% | 8% | 8% | |||||
* MAF = Minor Allele Frequency; ** rs75353978 SNP is a deletion of TT bases, it is indicated like delTT.