Table 4.

Tests for association between genetic variants and hereditary breast and ovarian cancer. All tests were carried out with a 95% confidence interval (CI).

Gene	Variant/Alleles	Risk Allele 1					Risk Allele 2
		Allele Freq. Difference	Heterozygous	Homozygous	Allele Positivity		Allele Freq. Difference	Heterozygous	Homozygous	Allele Positivity
		[1]↔[2]	[11]↔[12]	[11+]↔[22]	[11]↔[12+22]		[2]↔[1]	[22]↔[12]	[22]↔[11]	[11+12]↔[22]
BRCA1	rs8176318 (C/T)	2.4 (0.8–7.0)	1.1 (0.3–4.0)	7.5 (0.4–149.4)	1.7(0.5–5.7)		0.4 (0.1–1.3)	0.1 (0.01–3.5)	0.1 (0.01–2.7)	0.1 (0.01–2.7)
		0.118 (P)	0.918	0.078	0.372		0.118 (P)	0.1185	0.078	0.079
	rs12516 (C/T)	2.2 (0.9–5.4)	0.3 (0.05–1.3)	15.4 (0.9–277.7)	1.2 (0.4–3.3)		0.5 (0.2–1.1)	0.02 (0.001–0.5)	0.1 (0.004–1.2)	0.1 (0.003–1.0)
		0.082 (P)	0.078	0.001	0.79		0.082 (P)	0.001	0.0099	0.006
BRCA2	rs15869 (A/C)	1.5 (0.6–3.7)	0.3 (0.08–1.3)	10.7 (0.6–200.5)	0.9 (0.3–2.5)		0.7 (0.3–1.6)	0.03 (0.001–0.8)	0.1 (0.005–1.7)	0.1 (0.004–1.51)
		0.366 (P)	0.097	0.032	0.79		0.366 (P)	0.005	0.032	0.0218
	c.*457 (A/C)	1.9 (0.96–3.8)	0.4 (0.1–1.2)	11.3 (1.4–92.8)	1.1 (0.5–2.5)		0.5 (0.3–1.0)	0.04 (0.004–0.4)	0.1 (0.01–0.7)	0.1 (0.01–0.6)
		0.063 (P)	0.096	0.007	0.832		0.063 (P)	0.0005	0.007	0.0021

Cell contents: odds ratio (95% confidence interval) and p-value. rs8176318: Allele [1] = T; allele [2] = C, rs12516: allele [1] = T; allele [2] =C, rs15869: allele [1] = C; allele [2] = C; c.*457: allele [1] = C; allele [2] = A. Significative values are indicate in bold.