Table 2.

Quantification of structural lung disease at the time of the collection of the BALF samples from patients classified in cluster 1 or cluster 2. Lung disease was scored using either volumetric CT scans or the recently reported PRAGMA-CF methodology [40]. Calculated probabilities for rejecting the null hypothesis of samples coming from the same population in the context of the Mann-Whitney test were corrected for multiple comparisons using Bonferroni approach. BW, bronchial wall; Mu, Mucus; %Dis, volume proportion of the lung with airway disease [40]; % Bx, volume proportion of the lung with bronchiectasis [40]; %TA, volume proportion of the lung with trapped air [40], % Atelec, volume proportion of the lung with atelectasis [40].

Variable	Cluster 1	Cluster 2	p-Value
Bronchiectasis score	1 (0–2)	1 (0–3.5)	1
BW thickening score	10 (7–10)	8 (5–10)	1
Air trapped score	1 (0.75–4)	2 (1–4)	1
Mu. plugging score	0 (0–0.25)	0 (0–1)	1
% Dis	2.99 (2.39–4.13)	2.17 (1.1–3.8)	0.94
% Bx	0 (0–0.075)	0 (0–0.38)	1
% TA	2.06 (0.96–6.14)	1.28 (0.19–5.86)	1
% Atelec	0.06 (0–1.77)	0.2 (0–0.97)	1