Fig. 3.

E2f1 deficiency attenuates cardiac dysfunction in male mice 1-week post-MI. Male (blue) and female (red) E2f1^+/+(n = 25) and E2f1^+/+(n = 26) were subjected to echocardiography after 1-week post-MI. Representative m-mode images of E2f1^+/+ and E2f1^−/− hearts (a). Ablation of E2f1 attenuated acute heart failure as indicated by reduction in ventricular end-diastolic (b; p = 0.0024) and end-systolic (c; p = 0.0020) volumes and a concomitant improvement of ejection fraction (d; p = 0.0109). Gravimetric analysis of wet versus dry lung weight indicated no differences in pulmonary edema between E2f1^+/+ and E2f1^−/− groups (e). An unpaired Student’s t test was used to determine significance between E2f1^+/+ and E2f1^−/− groups