Fig. 4.

Loss of E2F1 reduces cardiac size without affecting cardiomyocyte hypertrophy after infarction. mRNA expression of markers of cardiac hypertrophy (a). Representative images of WGA-stained E2f1^+/+ and E2f1^−/− heart sections (b). Gravimetric analysis of heart size revealed reduced heart weight to tibia length (c) in E2f1^−/− mice. Cardiomyocyte cross-sectional area was measured in the border zone of the infarct (“BZ”; panel d), in the infarct zone (“IZ”; panel e), and remote zone (“RZ”; panel f). An unpaired Student’s t test was used to determine significance between E2f1^+/+ and E2f1^−/− groups