Fig. 8.

Cardiac capillary density and fibrosis are not improved during chronic heart failure in E2f1 deficient hearts. mRNA expression of Pdgfb at 4-week post-MI (a). Representative images of isolectin-stained of E2f1^+/+ and E2f1^−/− heart sections 4-week post-MI (b). Capillary density in border zone (“BZ”; c), infarct zone (“IZ”; d), and remote zones (“RZ”; e). Bcl2 mRNA (f). Representative TUNEL-stained of E2f1^+/+ and E2f1^−/− heart sections 4-week post-MI (g). Quantification of TUNEL-positive cells (h). Representative images for cardiac fibrosis (i) and quantification (j). An unpaired Student’s t test was used to determine significance between E2f1^+/+ and E2f1^−/− groups