Table 2.

E2f1 deficiency attenuates acute ventricular dilation and dysfunction

	E2f1+/+	E2f1−/−
HR (bpm)	548 ± 45	523 ± 45
SV (μL)	17 ± 5	20 ± 7
CO (mL/min)	9 ± 2	10 ± 3
LVIDd (mm)	5.5 ± 1	5.0 ± 0.7*
LVIDs (mm)	5.1 ± 1.2	4.3 ± 1.0*
FS (%)	9 ± 7	14 ± 10*
LVPWd (mm)	0.7 ± 0.3	0.7 ± 0.3
LVPWs (mm)	0.8 ± 0.4	0.9 ± 0.5
LVAWd (mm)	0.6 ± 0.3	0.8 ± 0.4*
LVAWs (mm)	0.7 ± 0.4	0.9 ± 0.5*

Male and female E2f1^−/− (n = 25) and their E2f1^+/+ (n = 26) littermates were subjected to echocardiography 1 week after MI. Indices of cardiac function were assessed. E2f1^−/− mice demonstrated shorter left ventricular diastolic and systolic inner diameter (LVIDd; p = 0.0268 and LVIDs; p = 0.0202) and higher lower fractional shortening (FS, p = 0.0437) compared to E2f1^+/+ mice. There were no changes in stroke volume (SV), heart rate (HR), or cardiac output (CO), diastolic or systolic left ventricular anterior wall diameter (LVAWd, LVAWs), diastolic or systolic left ventricular posterior wall diameter (LVPWd, LVPWs) between groups. An unpaired Student’s t test was used to determine significance between E2f1^+/+ and E2f1^−/− groups