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Schematic illustrating the conjugation of SN-38 to an oligonucleotide. A. An alkyl azide was tethered to the C20 hydroxyl of SN-38 through an ester linkage. B. The azide was then reacted with a commercially available oligonucleotide containing a terminal alkyne using copper-catalyzed azide–alkyne cyclo-addition chemistry to yield a SN38-conjugated oligonucleotide.
