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. Author manuscript; available in PMC: 2020 Jun 8.
Published in final edited form as: Bioconjug Chem. 2018 Feb 19;29(4):1111–1118. doi: 10.1021/acs.bioconjchem.7b00774

Figure 4.

Figure 4.

SN38-oligonucleotide Au-NPs exhibit toxicity against multiple Ewing sarcoma cell lines. A. Ewing sarcoma cell lines were treated with SN38-DNA Au-NPs (3 nM) and after 48 h apoptosis and cell death assessed by staining with annexin-V antibody and a viability dye followed by flow cytometry. The annexin-V and annexin-V/viability dye positive populations were then used to calculate the percentage of viable cells and normalized to either untreated control cells (A) or cells treated with the SN38-Scrambled Au-NPs (B) and are the mean ± s.e.m. from three independent experiments. *, P < 0.05; **, P < 0.005; ***, P < 0.001 when comparing untreated control cells (A) or cells treated with the SN38-Scrambled Au-NPs (B) and cells treated with SN-38 conjugated Au-NPs.