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. Author manuscript; available in PMC: 2020 Jun 8.
Published in final edited form as: Bioconjug Chem. 2018 Feb 19;29(4):1111–1118. doi: 10.1021/acs.bioconjchem.7b00774

Figure 6.

Figure 6.

SN38-oligonucleotide Au-NPs exhibit toxicity against Ewing sarcoma cells in vivo. TC71 xenotransplanted tumors were injected with PBS (n = 4), Survivin Au-NPs 75 nM (n = 4), SN38-Survivin Au-NPs 75 nM (n = 5), or SN38-EWS/FLI1 Au-NPs 75 nM (n = 5). After 48 h, the tumors were excised, dissociated, and stained with annexin-V antibody and a viability dye followed by flow cytometry. The annexin-V and annexin-V/viability dye positive populations were then used to calculate the percentage of viable TC71 cells. The data are normalized to tumors injected with PBS. ***, P < 0.0001 and *, <0.05 when comparing PBS with SN38-Survivin Au-NP and SN38-EWS/FLI1 Au-NP injected tumors, respectively.