Table 2.

Suppressive roles of m6A proteins and biological mechanisms exerted in human tumors

Cancer	Regulator	Role in cancer	Mechanism	Functional classification	Refs
GBM	METTL3 METTL14	Suppressor	Downregulate oncogenes like ADAM19	Suppress GSCs growth and self-renewal	[49]
HCC	METTL14	Suppressor	Interact with DGCR8 and modulate the primary miR-126 process	Suppress tumor invasion and metastasis	[100]
HCC	YTHDF2	Suppressor	Inhibit STAT3 phosphorylation by degrading IL11 and SERPINE2 mRNA; Activate MEK/ERK pathway, destabilizing EGFR mRNA	Inhibit inflammation, vascular reconstruction and metastatic progression	[101] [102]
CRC	METTL3	Suppressor	Regulate p38/ERK pathways	Suppress CRC cancer proliferation and migration	[103]
CRC	METTL14	Suppressor	Regulate primary miR-375 processing	Inhibit CRC cell growth and metastasis	[104]
PDAC	ALKBH5	Suppressor	Demethylate lncRNA KCNK15-AS1	Inhibit pancreatic cancer motility and EMT	[105]
PDAC	YTHDF2	Suppressor	Destabilize YAP mRNA	Inhibit cancer migration, invasion, and adhesion ability	[79]
BCA	METTL14	Suppressor	Target Notch1	Inhibit bladder TIC self-renewal and bladder tumorigenesis	[106]
RCC	METTL3	Suppressor	Change EMT and PI3K-Akt-mTOR pathways	Suppress proliferation, migration, invasion function and cell cycle of RCC	[107]
RCC	FTO	Suppressor	Increase expression of PGC-1α	Impair tumor growth and induce apoptosis via regulating mitochondrial biogenesis and oxidative phosphorylation	[108]
EC	METTL3/METTL14 METTL14	Suppressor	Active AKT signaling pathway	Inhibit the proliferation and tumorigenicity of in vitro and in vivo	[109]
Melanoma	YTHDF1	Suppressor	Bind HINT2	Restrain cell growth and migratory ability	[110]

GBM glioblastoma; HCC hepatocellular carcinoma; CRC colorectal cancer; PDAC pancreatic cancer; BCA bladder cancer; RCC renal cell carcinoma; EC Endometrial cancer