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. 2020 Jun 8;11:224. doi: 10.1186/s13287-020-01737-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Exosomes derived from MSCs inhibit apoptosis after myocardial infarction. a Expression levels of the apoptotic proteins BAD, BAX, BCL-2, and Cleaved-CASPASE-3 were evaluated in cardiac tissue sections from sham-operated rats and coronary-ligated rats that received either no therapy (PBS), MSC exosomes, or exosomes from MSCs treated after vessel occlusion with GW4869 immediately (N = 5 per group). Western blot analysis of protein lysates obtained from the infarct border zone. Quantitative analysis of BAD, BAX, BCL-2, and Cleaved-CASPASE-3 is shown in the lower panel. b Cell injury was determined by TUNEL assay. Fluorescence staining with vital dyes shown in blue indicates live cardiomyocytes, whereas ethidium homodimer-1 staining labels dead cells green. The percentage of cardiomyocytes death is shown in the right panels. Each experiment was repeated 3 times. *p < 0.05, **p < 0.01, ***p < 0.001 for MI vs. sham. ^#p < 0.05 for MI + exosome vs. MI