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. 2020 Jun 8;11:224. doi: 10.1186/s13287-020-01737-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Overexpression of miR-210 in MSC exosomes leads to improvement of cardiac function and infarct size in vivo at 1 month after MI. a–c Representative photographs of M-mode echocardiography. Quantitative analysis of echocardiography (N = 4 per group). FS, fractional shortening; EF, ejection fraction; LVIDd, left ventricular internal diameter end-diastolic; LVIDs, left ventricular internal diameter end-systolic. d Masson Trichrome staining of whole heart tissue sections 28 days post-ligation and treatment with PBS, MSC exosomes, exosomes derived from MSCs treated with GW4869, MSCs-exo^miR210, MSCs-exo^anti-miR210, or MSCs-exo^Vehicle. Percentage of tissue fibrosis is quantified and presented. N = 4 per group. e Representative photographs of PET-CT of rats from the respective treatment groups. N = 3 per group. ***p < 0.001, ****p < 0.0001 for MI vs. sham. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001 for MI + exosome, GW4869, MSCs-exo^miR210, MSCs-exo^anti-miR210, MSCs-exo^Vehicle vs. MI. ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001 for MSCs-exo^miR210, MSCs-exo^anti-miR210 vs. MSCs-exo^Vehicle