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. 2020 Jun 8;21:135. doi: 10.1186/s13059-020-02049-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — caQTL and clQTL rs2692224 regulate chromatin accessibility and chromosomal interaction at CAD gene FN1. aFN1 locus, showing caQTL and clQTL rs2692224. b Bar graphs show allele-specific enrichment of chromatin accessibility at rs2692224 as identified by allele-specific qPCR. c mRNA levels and d chromatin accessibility at the TSS region of FN1 were suppressed by CRISPRi-KRAB targeting at rs2692224. e Diagram (top) shows the chromosomal loops between rs2692224 and TSS/TES of FN1. 3C-PCR (bottom) indicates the differential chromosomal contacts from rs2692224 to TSS of FN1. Pre-post: allele frequencies in the QTL regression data. Shown are means ± SD; n = 3; ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05