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Characteristics of the 200 studies included in this review
| Trial design | Superiority | 157 (79%) |
| Non-inferiority | 33 (17%) | |
| Equivalence | 3 (2%) | |
| Unclear | 7 (4%) | |
| Size | Median = 145, interquartile range = 82–400 | |
| Multicentre | Yes | 110 (55%) |
| No | 83 (42%) | |
| Unclear | 7 (4%) | |
| Funding | Public, charity, or public and charity | 68 (34%) |
| Solely industry | 38 (19%) | |
| Others (include combinations) | 40 (20%) | |
| No stated funding | 54 (27%) | |
