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. 2020 Jun 8;21:140. doi: 10.1186/s12931-020-01403-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The effect of caffeine on SFTPC expression and apoptosis. After 14 days of high oxygen exposure, SFTPC protein expression was significantly decreased, and the number of apoptotic cells was increased. Caffeine treatment reversed these effects. a Representative SFTPC-positive cells in the lungs of each group as determined by IF staining (microscopy, × 200). Scale bars = 100 μm. b The protein level of SFTPC in lung as determined by western blotting. c Representative images and an analysis of TUNEL staining (microscopy, × 200). Scale bars = 100 μm. The values are the mean ± SD; n = 8 fields/group. **P < 0.01 Hyperoxia (HO) group versus Normoxia (NO) group, ^##P < 0.01 Hyperoxia + Caffeine (HC) group versus HO group, ^▲P < 0.05 NO group versus HC group,^ΨΨP < 0.01 NO group versus HC group