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. 2020 Jun 8;21:140. doi: 10.1186/s12931-020-01403-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The effect of caffeine on the NF-κB pathway and inflammasome proteins in neonatal mouse lung. Hyperoxia exposure led to the activation of the NF-κB pathway and inflammasome proteins. Caffeine treatment ameliorated this hyperoxia-induced change. a Representative image and semiquantitative analysis of ASC protein expression in lung tissue. b Representative image and semiquantitative analysis of Caspase-1 protein expression in lung tissue. c Representative image and semiquantitative analysis of Caspase-3 protein expression in lung tissue. d Representative image and semiquantitative analysis of NLRP3 protein expression in lung tissue. e Representative image and semiquantitative analysis of phosphor-NF-κB and NF-κB protein expression in lung tissue. f Representative image and semiquantitative analysis of phosphor-IκBα and IκBα protein expression in lung tissue. GAPDH was the loading control. The values are the mean ± SD; n = 6 mice/group. **P < 0.01 Hyperoxia (HO) group versus Normoxia (NO) group, ^##P < 0.01 Hyperoxia + Caffeine (HC) group versus HO group, ^ΨP < 0.05, ^ΨΨP < 0.01 NO group versus HC group