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. 2020 May 21;10(5):796. doi: 10.3390/biom10050796

Figure 7.

Figure 7

Intrinsic disorder predisposition and structural characterization of UCHL1 and UCHL5. (a) Disorder profile of human UCHL1 (UniProt ID: P09936) (b) Disorder profile of human UCHL5 (UniProt ID: Q9Y5K5) (a1) Crystal structure of UCHL1 (PDB ID: 4JKJ). (b1) Crystal structure of UCHL5 (PDB ID: 4UEL). In (a,b), intrinsic disorder profiles obtained from disorder predictors, such as PONDR® VSL2, PONDR® VL3, PONDR® VLXT, PONDR® FIT and IUPred, are depicted by black, orange, blue, yellow, and purple lines respectively. Mean disorder profile, calculated from the average of five predictor-specific per-residue disorder profiles, is represented by the olive color. Predicted disorder scores above 0.5 are considered disordered residues/regions. The light-olive shadow around the mean curve represents the error distribution for the mean. The light-yellow shadow around the PONDR® FIT curve shows the error distribution for PONDR® FIT. In (a1,b1), UCHL1 and UCHL5 are represented by faded blue color; in Plot (b1), the DEUBAD domain of the RPN13 protein and Ub in complex with UCHL5 are shown in orange color. Disordered residues are shown in salmon pink color. In (a2,b2), the functional disorder profile of UCHL1 and UCHL5 proteins using the D2P2 server have been shown.