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. 2020 May 21;10(5):796. doi: 10.3390/biom10050796

Figure 11.

Figure 11

Intrinsic disorder predisposition of human PSMD2 (a), PSMD4 (b), and PSMD14 (c). Plots show the intrinsic disorder profile generated by a set of per-residue disorder predictors, such as PONDR® VSL2, PONDR® VL3, PONDR® VLXT, PONDR® FIT, and IUPred. The corresponding outputs are depicted by black, orange, blue, yellow, and purple curves respectively. Mean disorder profile is calculated from the average of five predictor-specific per-residue disorder profiles and shown by the olive color curve. Predicted disorder scores above 0.5 are considered disordered residues/regions. Light-olive shadow around the mean curve represents the error distribution for the mean. The light-yellow shadow around the PONDR® FIT curve shows the error distribution for that predictor. (d) portrays the cryo-EM structures of substrate-engaged human 26S proteasome in seven different conformational states (PDB ID: 6MSB); all three reported proteins PSMD2 (blue), PSMD4 (wine) and PSMD14 (olive) are shown in this complex. D2P2 server-based functional disorder profiles are shown in (a1,b1,c1).