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Inhibitory activity of the three synthesized molecules
| Compound | Inhibition for CDK4 at 10 μM (%) | Inhibition for CDK4 at 100 μM (%) | Inhibition for Pim1 at 10 μM (%) |
|---|---|---|---|
| MJ-4 | 10.96 ± 2.57 | 72.77 ± 1.24 | < 10 |
| MJ-115 | 35.82 ± 3.75 | 90.74 ± 1.28 | 10.38 ± 6.39 |
| MJ-1055 | 21.06 ± 1.45 | 81.5 ± 2.2 | 99.64 ± 0.08 |
The tests were performed with at least two replicates
Staurosporine was tested as the positive control. Its IC50 values for Pim1 and CDK4 are 46 nM and 30 nM, respectively
