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. 2020 Jun 7;11:2041731420926918. doi: 10.1177/2041731420926918

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — IGFBP5 and CXCL12 released from the MSC/POC ECM-based TEBs enhanced the osteogenic differentiation and migration. (a) Release profiles and cumulative total proteins of IGFBP5 and CXCL12 over 15 days. (b) POCs released more IGFBP5 and CXCL12 owing to the indirect co-culture with MSCs. (c) IGFBP5 antibody reduced the expression of osteogenic marker genes, including Runx2, Col1a1, and Osx, GAPDH was used as a loading control. (d) Representative images and qualitative analysis of MSC Alizarin Red S staining and ALP staining. Scale bars are 1 cm. (e, f) Qualitative analysis of the MSC invasion ability by the transwell assay and the migration ability by the wound healing assay. Scale bars are 200 μm. **p < 0.01, *p < 0.05, NS: no significance.