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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Expert Opin Drug Deliv. 2020 Feb 19;17(4):439–461. doi: 10.1080/17425247.2020.1729119

Figure 5.

Figure 5.

The effect of liposomal fasudil on the pulmonary hemodynamics in Sugen/hypoxia PAH rats after administration of (a) fasudil in no-CAR-liposomes, (b) CAR pretreatment followed by fasudil in no-CAR-liposomes and (c) fasudil in CAR-liposomes. (d) Targeting indices of fasudil after IT administration in various forms. The dose of fasudil was 3 mg/kg (rat body weight) or liposomes containing equivalent amount of fasudil and the dose of CAR was 0.5 mg/kg (data represent mean ± SD, n = 3; *p < 0.05, §p < 0.005, ?p < 0.001).