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Schematic representations of Tau filament core-fold from recently published cryo-EM structures of brain-derived and in vitro generated Tau filaments. Tyr-310 residue is buried in the interior (red) of the Tau single filament-fold in structures derived from AD, Pick's disease, CTE, and CBD-Tau, or exposed in the exterior (green) in in vitro derived Tau structures. Adapted from Refs. 29, 51, and 63–65.
