Figure 12.
Domains swaps in SH domains. A, SH3 domains can swap from the RT, n-Src, and distal loops. Nck1-SH3.1 (black for the monomer, yellow for a swapped example) swaps from the n-Src loop, as do EPS8 (PDB entry 1I07; magenta) and c-Src (PDB entry 4JZ3; pale cyan). The SH3C domain of CRK-like (PDB entry 2BZY; blue) swaps from the RT loop, and the p47phox SH3 domain (PDB entry 1UEC; green) swaps from the distal loop. B, the SH2 domain of Nck1 can also swap (PDB entry 2CI8; hues of blue), leading to the possibility of a double domain swap of this adapter protein. The phosphopeptide-bound monomer (PDB entry 2CIA; yellow) is shown for reference. The N terminus is marked.