Table 3.
Urinalysis and urine chemistry values of cats belonging to the three study groups: Healthy (n = 22), FeMV (n = 14) and CKD (n = 21).
| Variable | RI | Healthy (n = 22) | FeMV (n = 14) | CKD (n = 21) | p Value |
|---|---|---|---|---|---|
| USG | >1035 | 1067 (1040–1080) | 1054 (1022–1060) | 1017 (1008–1040) | <0.001 * |
| USG < 1035, n (%) | – | – | 1/14 (7 %) | 19/21 (90 %) | <0.001 |
| uCreatinine mg/dL | 120–593 | 406.5 (117.8–575.6) | 227.2 (83.0–489.8) | 112.7 (48.4–489.6) | <0.001 * |
| uUrea mg/dL | 1500–10700 | 7597.8 (3650.6–9235.1) | 5174.9 (1625.2–6508.3) | 2225.8 (967.6–6478.8) | <0.001 * |
| uTP mg/dL | 21–134 | 41.14 (22.09–151.24) | 41.97 (16.44–172.74) | 33.42 (5.96–337.90) | 0.244 |
| UPC | 0.01–0.4 | 0.1 (0.04–0.25) | 0.20 (0.08–1.03) | 0.23 (0.10–0.80) | <0.001 † |
| UPC 0.2–0.4, n (%) | – | – | 5/13 (38%) | 9/21 (43%) | 0.803 |
| UPC > 0.4, n (%) | – | – | 1/13 (8%) | 6/21 (29%) | 0.149 |
| uGlucose mg/dL | 4.0–14.0 | 8.0 (5.0–16.1) | 9.9 (3.3–139.0) | 2 (0–1408.0) | <0.001 ‡ |
| uNa mEq/L | 49.0–375.0 | 210.40 (20.40–296.0) | 83.10 (16.20–217.10) | 78.80 (13.10–298.20) | <0.001 † |
| uNa/uCrea | 0.15–1.0 | 0.51 (0.10–0.72) | 0.31 (0.07–1.23) | 0.76 (0.11–1.20) | 0.040 ‡ |
| FE Na% | 0–0.97 | 0.49 (0.08–0.88) | 0.19 (0.04–0.78) | 1.13 (0.21–6.11) | <0.001 ‡ |
| uK mEq/L | 60–231 | 134.30 (62.50–230.40) | 149.95 (85.0–200.40) | 53.50 (19.0–169.30) | <0.001 ‡ |
| uK/uCrea | 0.16–0.66 | 0.34 (0.15–0.64) | 0.68 (0.22–1.30) | 0.47 (0.16–0.76) | <0.001 * |
| FE K% | 7.0–22.0 | 11.87 (6.20–22.79) | 12.69 (8.63–27.12) | 38.96 (7.91–128.76) | <0.001 ‡ |
| uCa mg/dL | 1.0–10.0 | 2.40 (1.0–11.60) | 2.05 (1.10–3.50) | 2.40 (0.80–9.40) | 0.586 |
| uCa/uCrea | 0–0.03 | 0.01 (0–0.03) | 0.01 (0–0.03) | 0.02 (0–0.14) | <0.001 ‡ |
| FE Ca% | 0–0.26 | 0.09 (0.05–0.45) | 0.10 (0.04–0.26) | 0.72 (0.10–11.15) | <0.001 ‡ |
| uP mg/dL | 90.0–385.0 | 187.70 (105.20–381.30) | 230.0 (103.50–377.30) | 58.10 (9.7–268.20) | <0.001 ‡ |
| uP/uCrea | 0.25–1.13 | 0.51 (0–0.89) | 1.16 (0.32–2.26) | 0.55 (0.04–0.87) | <0.001 ¶ |
| FE P% | 0–40 | 16.51 (8.28–37.32) | 17.20 (9.54–38.15) | 31.55 (3.02–54.99) | 0.002 ‡ |
| uCl mEq/L | 51–366 | 179.40 (85.0–330.0) | 87.0 (10.50–133.0) | 190.50 (56.0–386.0) | <0.001 ‡ |
| uCl/uCrea | 0.13–1.10 | 0.43 (0.15–1.08) | 1.02 (0.14–2.47) | 0.64 (0.09–1.29) | 0.004 † |
| FE Cl% | 0.18–1.26 | 0.55 (0.20–1.08) | 0.80 (0.26–1.97) | 1.42 (0.21–9.15) | <0.001 ‡ |
| uMg mg/dL | 0.76–17 | 11.06 (3.0–19.40) | 8.07(1.04–14.64) | 4.15 (0.76–9.70) | 0.001 ‡ |
| uMg/uCrea | 0–0.05 | 0.03 (0.01–0.06) | 0.05 (0–0.09) | 0.04 (0–0.11) | 0.051 † |
| FE Mg% | 0.05–3.23 | 1.92 (0.41–3.22) | 1.72 (0.21–3.87) | 6.38 (0.15–31.61) | <0.001 ‡ |
| Total bands number | – | 13 (9–15) | 17 (5–24) | 15 (6–21) | 0.016 ∞ |
| HMM number | – | 6 (5–7) | 6 (2–8) | 4 (1–9) | 0.049 ‡ |
| LMM number | – | 7 (3–10) | 11 (3–17) | 9 (5–16) | 0.024 † |
Data are reported as median and range (in brackets). FeMV = Feline morbillivirus; CKD = chronic kidney disease; RI = reference interval; USG = urine specific gravity; uCreatinine = urinary creatinine; uUrea = urinary urea; uTP = urinary total proteins; UPC = urine protein:creatinine ratio; uGlucose = urinary glucose; uNa = urinary sodium; FE Na = fractional excretion of sodium; uK = urinary potassium; FE K = fractional excretion of potassium; uCa = urinary calcium; FE Ca = fractional excretion of calcium; uP = urinary phosphorus; FE P = fractional excretion of phosphorus; uCl = urinary chloride; FE Cl = fractional excretion of chloride; uMg = urinary magnesium; FE Mg = fractional excretion of magnesium; HMM = high molecular mass protein; LMM = low molecular mass protein; * Statistically significant difference among the three study groups; † Statistically significant difference in healthy compared with CKD and FeMV cats; ‡ Statistically significant difference in CKD compared with healthy and FeMV cats; ¶ Statistically significant difference in FeMV compared with CKD and healthy cats; ∞ Statistically significant difference between FeMV and healthy cats.