Table 2.

Left Ventricular Ejection Fraction and CSF Biomarkers

	Primary Models				Sensitivity Models Excluding CVD and Atrial Fibrillation*
	n	β	95% CI	p	n	β	95% CI	p
Beta-Amyloid42
Main Effects	152	−6.5	−12.7, −0.3	0.04	144	−6.0	−12.5, 0.4	0.07
LVEF x Sex Interaction	152	−13.0	−25.7, −0.3	0.04	144	−13.7	−26.8, −0.5	0.04
Males	103	−1.5	−9.6, 6.7	0.72	99	−1.0	−9.4, 7.5	0.82
Females	49	−12.1	−22.6, −1.7	0.02	45	−12.7	−23.8, −1.7	0.03
LVEF x Diagnostic Interaction	137	−12.1	−24.8, 0.6	0.06	129	−13.6	−26.8, −0.4	0.04
NC Sample	80	0.3	−9.1, 9.8	0.95	74	1.5	−8.5, 11.5	0.76
MCI Sample	57	−10.8	−19.4, −2.2	0.01	55	−10.9	−19.7, −2.1	0.02
Total Tau
Main Effects	152	−0.9	−7.6, 5.8	0.79	144	−0.7	−7.6, 6.2	0.85
LVEF x Sex Interaction	152	−3.0	−16.9, 11.0	0.67	144	−1.2	−15.5, 13.1	0.87
Males	103	−0.1	−7.2, 7.1	0.98	99	−0.6	−7.9, 6.8	0.88
Females	49	−2.7	−18.7, 13.4	0.74	45	−2.7	−19.1, 13.8	0.75
LVEF x Diagnostic Interaction	137	20.9	6.9, 35.0	0.004	129	19.2	4.6, 33.7	0.01
NC Sample	80	−9.7	−17.1, −2.4	0.01	74	−8.7	−16.3, −1.2	0.02
MCI Sample	57	10.2	−3.4, 23.8	0.14	55	9.7	−4.5, 23.9	0.18
Phosphorylated Tau
Main Effects	152	−0.3	−1.1, 0.5	0.47	144	−0.2	−1.0, 0.5	0.53
LVEF x Sex Interaction	152	−0.5	−2.1, 1.1	0.55	144	−0.3	−1.9, 1.3	0.72
Males	103	−0.2	−1.0, 0.7	0.74	99	−0.2	−1.1, 0.7	0.68
Females	49	−0.6	−2.4, 1.1	0.48	45	−0.6	−2.4, 1.1	0.45
LVEF x Diagnostic Interaction	137	2.6	1.0, 4.2	0.002	129	2.3	0.7, 3.9	0.006
NC Sample	80	−1.4	−2.3, −0.5	0.003	74	−1.3	−2.2, −0.3	0.008
MCI Sample	57	1.1	−0.4, 2.6	0.13	55	1.0	−0.5, 2.6	0.19

Note.

^*Sensitivity analyses excluded 8 participants with cardiovascular disease or atrial fibrillation. Models were adjusted for age, race/ethnicity, education, Framingham Stroke Risk Profile (FSRP) minus age, and cognitive diagnosis. CI=confidence interval. CSF=cerebrospinal fluid. CVD=cardiovascular disease. MCI=mild cognitive impairment. NC=normal cognition.FIGURES