Supplementary Table 1.
The relationship between co-expressed genes and respiratory system diseases based on the CTD database.
| Gene symbol | Gene ID | Disease name | Disease ID | Direct evidence | Inference network | Inference score | Reference count |
|---|---|---|---|---|---|---|---|
| BPIFA1 | 51297 | Rhinitis | MESH: D012220 | Particulate Matter | Tobacco Smoke Pollution | Vehicle Emissions | 12.67 | 3 | |
| BPIFA1 | 51297 | Rhinitis, allergic | MESH: D065631 | Particulate Matter | Soot | 8.45 | 2 | |
| BPIFA1 | 51297 | Rhinitis, allergic, seasonal | MESH: D006255 | Particulate Matter | 3.57 | 1 | |
| BPIFA1 | 51297 | Asthma | MESH: D001249 | Acetaminophen | Arsenic | Particulate Matter | Soot | Tobacco Smoke Pollution | Vehicle Emissions | 21.02 | 29 | |
| BPIFA1 | 51297 | Asthma, occupational | MESH: D059366 | Silicon Dioxide | 3.35 | 1 | |
| BPIFA1 | 51297 | Nose diseases | MESH: D009668 | Propylthiouracil | Tobacco Smoke Pollution | 9.59 | 4 | |
| CCL26 | 10344 | Asthma | MESH: D001249 | Aerosols | Antigens, Dermatophagoides | Arsenic | Cadmium | Dexamethasone | Ozone | Resveratrol | Tobacco Smoke Pollution | Zinc | 27.99 | 28 | |
| CCL26 | 10344 | Rhinitis, allergic, perennial | MESH: D012221 | Ozone | 3.73 | 1 | |
| CCL26 | 10344 | Rhinitis, allergic | MESH: D065631 | Atrazine | 2.83 | 1 | |
| CCL26 | 10344 | Rhinitis | MESH: D012220 | Tobacco Smoke Pollution | 2.6 | 1 | |
| CCL26 | 10344 | Nose diseases | MESH: D009668 | Lipopolysaccharides | Propylthiouracil | Tobacco Smoke Pollution | 14.31 | 5 | |
| CCL26 | 10344 | Sinusitis | MESH: D012852 | Tobacco Smoke Pollution | 2.9 | 1 | |
| CPA3 | 1359 | Rhinitis | MESH: D012220 | Tobacco Smoke Pollution | Vehicle Emissions | 6.86 | 2 | |
| CPA3 | 1359 | Asthma | MESH: D001249 | Acetaminophen | Decitabine | epigallocatechin gallate | Tobacco Smoke Pollution | trimellitic anhydride | Vehicle Emissions | 18.84 | 19 | |
| CPA3 | 1359 | Nose diseases | MESH: D009668 | Tobacco Smoke Pollution | 3.4 | 2 | |
| CPA3 | 1359 | Sinusitis | MESH: D012852 | Acetaminophen | Tobacco Smoke Pollution | 7.83 | 2 | |
| CST1 | 1469 | Rhinitis, allergic, seasonal | MESH: D006255 | Marker/mechanism | 1 | ||
| CST1 | 1469 | Rhinitis, allergic | MESH: D065631 | Air Pollutants | 3.83 | 1 | |
| CST1 | 1469 | Rhinitis | MESH: D012220 | Air Pollutants | 3.6 | 1 | |
| CST1 | 1469 | Asthma | MESH: D001249 | Air Pollutants | Methotrexate | Tretinoin | 9.41 | 14 | |
| CST1 | 1469 | Asthma, occupational | MESH: D059366 | Silicon Dioxide | 3.45 | 1 | |
| CST2 | 1470 | Asthma, occupational | MESH: D059366 | Silicon Dioxide | 3.85 | 1 | |
| FETUB | 26998 | Rhinitis | MESH: D012220 | Tobacco Smoke Pollution | Vehicle Emissions | 5.71 | 2 | |
| FETUB | 26998 | Rhinitis, allergic | MESH: D065631 | Atrazine | 2.66 | 1 | |
| FETUB | 26998 | Nose diseases | MESH: D009668 | cobaltous chloride | Tobacco Smoke Pollution | 7.86 | 3 | |
| FETUB | 26998 | Sinusitis | MESH: D012852 | Acetaminophen | Tobacco Smoke Pollution | 6.66 | 2 | |