Table 1.
The Gene Ontology (GO) terms enrichment for the co-expressed genes of rhinitis and asthma.
| Gene/product | GO class (direct) | Evidence | Reference |
|---|---|---|---|
| BPIFA1 | Protein binding | IPI | PMID: 25416956 |
| Extracellular region | IDA | PMID: 11425234 | |
| Extracellular space | IDA | PMID: 21805676 | |
| Lipid binding | IEA | GO_REF: 0000037 | |
| Antimicrobial humoral response | TAS | Reactome: R-HSA-6803157 | |
| Antibacterial humoral response | IDA | PMID: 23499554 | |
| Innate immune response | IDA | PMID: 23499554 | |
| Regulation of liquid surface tension | IDA | PMID: 23499554 | |
| Multicellular organismal water homeostasis | IDA | PMID: 24124190 | |
| Defense response to virus | IEP | PMID: 21805676 | |
| Antimicrobial humoral immune response mediated by antimicrobial peptide | IEP | PMID: 21805676 | |
| Negative regulation of single-species biofilm formation in or on host organism | IMP | PMID: 23499554 | |
| Regulation of sodium ion transmembrane transport | IDA | PMID: 24124190 | |
| CCL26 | Positive regulation of endothelial cell proliferation | IDA | PMID: 19525930 |
| Monocyte chemotaxis | IDA | PMID: 10373330 | |
| Protein binding | IPI | PMID: 28381538 | |
| Extracellular space | IDA | PMID: 10373330 | |
| Chemotaxis | TAS | PMID: 10373330 | |
| Signal transduction | NAS | PMID: 10373330 | |
| Cell–cell signaling | TAS | PMID: 10373330 | |
| Chemokine activity | IDA | PMID: 10373330 | |
| T cell chemotaxis | IDA | PMID: 10373330 | |
| Positive regulation of cell migration | IDA | PMID: 19525930 | |
| Positive regulation of actin filament polymerization | IDA | PMID: 19525930 | |
| CCR3 chemokine receptor binding | IDA | PMID: 11425309 | |
| Positive regulation of GTPase activity | IDA | PMID: 19525930 | |
| Receptor ligand activity | IDA | PMID: 11425309 | |
| Positive regulation of chemotaxis | IDA | PMID: 10373330 | |
| Chemokine-mediated signaling pathway | IDA | PMID: 10373330 | |
| CCR chemokine receptor binding | IBA | PMID: 21873635 | |
| Positive regulation of GTPase activity | IBA | PMID: 21873635 | |
| Lymphocyte chemotaxis | IBA | PMID: 21873635 | |
| Chemokine activity | IBA | PMID: 21873635 | |
| Monocyte chemotaxis | IBA | PMID: 21873635 | |
| Cellular response to tumor necrosis factor | IBA | PMID: 21873635 | |
| Extracellular space | IBA | PMID: 21873635 | |
| Inflammatory response | IBA | PMID: 21873635 | |
| Chemokine-mediated signaling pathway | IBA | PMID: 21873635 | |
| G protein-coupled receptor signaling pathway | IBA | PMID: 21873635 | |
| Cellular response to interleukin-1 | IBA | PMID: 21873635 | |
| Neutrophil chemotaxis | IBA | PMID: 21873635 | |
| Positive regulation of ERK1 and ERK2 cascade | IBA | PMID: 21873635 | |
| Cellular response to interferon-gamma | IBA | PMID: 21873635 | |
| CPA3 | Angiotensin maturation | TAS | Reactome: R-HSA-2028294 |
| Metallocarboxypeptidase activity | TAS | PMID: 1629626 | |
| Extracellular region | TAS | Reactome: R-HSA-2028294 | |
| Proteolysis | TAS | PMID: 2708524 | |
| Zinc ion binding | IEA | GO_REF: 0000002 | |
| Transport vesicle | IEA | GO_REF: 0000039 | |
| Secretory granule | NAS | PMID: 2594780 | |
| Collagen-containing extracellular matrix | HDA | PMID: 27559042 | |
| Metallocarboxypeptidase activity | IBA | PMID: 21873635 | |
| Proteolysis | IBA | PMID: 21873635 | |
| Extracellular space | IBA | PMID: 21873635 | |
| CST1 | Detection of chemical stimulus involved in sensory perception of bitter taste | IDA | PMID: 24248522 |
| Cysteine-type endopeptidase inhibitor activity | IEA | GO_REF: 0000037 | |
| Protein binding | IPI | PMID: 25416956 | |
| Extracellular space | HDA | PMID: 22664934 | |
| Negative regulation of endopeptidase activity | IEA | GO_REF: 0000108 | |
| Extracellular space | IBA | PMID: 21873635 | |
| CST2 | Detection of chemical stimulus involved in sensory perception of bitter taste | IDA | PMID: 24248522 |
| Cysteine-type endopeptidase inhibitor activity | IEA | GO_REF: 0000037 | |
| Protein binding | IPI | PMID: 25416956 | |
| Extracellular space | HDA | PMID: 22664934 | |
| Negative regulation of endopeptidase activity | IEA | GO_REF: 0000108 | |
| Extracellular space | IBA | PMID: 21873635 | |
| FETUB | Cysteine-type endopeptidase inhibitor activity | IEA | GO_REF: 0000002 |
| Single fertilization | ISS | GO_REF: 0000024 | |
| Binding of sperm to zona pellucida | ISS | GO_REF: 0000024 | |
| Metalloendopeptidase inhibitor activity | ISS | GO_REF: 0000024 | |
| Negative regulation of endopeptidase activity | ISS | GO_REF: 0000024 | |
| Extracellular exosome | HDA | PMID: 23533145 | |
| Binding of sperm to zona pellucida | IBA | PMID: 21873635 | |
| Negative regulation of endopeptidase activity | IBA | PMID: 21873635 | |
| Metalloendopeptidase inhibitor activity | IBA | PMID: 21873635 | |
| Extracellular region | IBA | PMID: 21873635 | |
| Endopeptidase inhibitor activity | IBA | PMID: 21873635 |