Table 2.
The Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment among predicted miRNAs and co-DEGs.
| Genes | Predicted miRNAs | Category | P value | |
|---|---|---|---|---|
| BPIFA1 | hsa-miR-195-5p | KEGG pathway | Fatty acid biosynthesis | 1.04E-07 |
| hsa-miR-16-5p | Adherens junction | 1.70E-07 | ||
| hsa-miR-424-5p | TGF-beta signaling pathway | 3.28E-05 | ||
| hsa-miR-497-5p | GO terms | Neurotrophin TRK receptor signaling pathway | 1.79E-31 | |
| hsa-miR-15b-5p | cell death | 1.41E-28 | ||
| Response to stress | 1.41E-28 | |||
| Blood coagulation | 1.84E-25 | |||
| Fc-epsilon receptor signaling pathway | 5.45E-19 | |||
| Immune system process | 3.87E-15 | |||
| Activation of signaling protein activity involved in unfolded protein response | 3.77E-14 | |||
| Toll-like receptor 10 signaling pathway | 1.22E-13 | |||
| Epidermal growth factor receptor signaling pathway | 1.82E-13 | |||
| Toll-like receptor TLR1: TLR2 signaling pathway | 1.06E-12 | |||
| Toll-like receptor TLR6: TLR2 signaling pathway | 1.06E-12 | |||
| CCL26 | hsa-miR-326 | KEGG pathway | Steroid biosynthesis | 8.04E-10 |
| hsa-miR-615-5p | ECM-receptor interaction | 3.39E-08 | ||
| hsa-miR-559 | GO terms | Neurotrophin TRK receptor signaling pathway | 5.30E-26 | |
| hsa-miR-335-5p | Small molecule metabolic process | 5.89E-21 | ||
| hsa-miR-548d-5p | Blood coagulation | 8.06E-18 | ||
| Cellular protein modification process | 4.43E-15 | |||
| Fc-epsilon receptor signaling pathway | 3.94E-13 | |||
| Cellular nitrogen compound metabolic process | 3.94E-13 | |||
| Immune system process | 7.59E-11 | |||
| CPA3 | hsa-miR-125a-3p | KEGG pathway | Adherens junction | 2.60E-07 |
| hsa-miR-155-5p | Hippo signaling pathway | 1.21E-05 | ||
| hsa-miR-196a-5p | TGF-beta signaling pathway | 1.96E-05 | ||
| hsa-miR-196b-5p | Lysine degradation | 4.43E-05 | ||
| GO terms | cellular nitrogen compound metabolic process | 6.05E-108 | ||
| gene expression | 7.55E-68 | |||
| biosynthetic process | 8.95E-64 | |||
| cellular protein modification process | 8.70E-52 | |||
| CST1 | hsa-miR-452-5p | KEGG pathway | ECM-receptor interaction | 0.000132 |
| hsa-miR-608 | Hippo signaling pathway | 0.00019 | ||
| hsa-miR-138-5p | Adherens junction | 0.00019 | ||
| hsa-miR-4685-5p | Apoptosis | 0.005037 | ||
| hsa-miR-1321 | Focal adhesion | 0.005037 | ||
| GO terms | Cellular nitrogen compound metabolic process | 2.81E-42 | ||
| Gene expression | 2.91E-40 | |||
| Biosynthetic process | 7.87E-34 | |||
| mRNA metabolic process | 8.00E-21 | |||
| Response to stress | 8.00E-21 | |||
| RNA metabolic process | 1.38E-17 | |||
| Symbiosis, encompassing mutualism through parasitism | 1.97E-17 | |||
| Cellular component assembly | 2.11E-17 |