Figure EV2. Theophylline shows therapeutic potential to ameliorate cognitive and motor functions by recovery of class 1 HDACs activity.

• A
  Escape latency of mice in the Morris water maze task following 2 months of HDAC1 activator treatment. N = 5 mice per group. *P = 0.0469 (5th session)/**P = 0.007 or ^#### P < 0.0001 (6th session) by multiple comparison. * Tg+Theophyllinemice versus Tg+Vehicle mice, ^# Tg+5104434 mice versus Tg+Vehicle mice.
• B
  Scores of mice in the rotarod test. N = 5 mice per group. *P = 0.0371 by Student's t‐test.
• C
  Nuclear HDAC1 activity in mice following 2 months of theophylline treatment. N = 5 mice per group. **P = 0.0013 by Student's t‐test. TSA: nuclear extracts that were treated with Trichostatin A (TSA, an HDAC inhibitor) as a negative control for HDAC1‐transferred fluorescent activity during the HDAC1 activity assay.

Data information: All data are presented as mean ± SEM.