Figure 6. HDAC1 activator ameliorates cognitive and motor deficits in FTLD‐TDP Tg mice. HDAC1 activator ameliorates cognitive and motor deficits in FTLD‐TDP Tg mice.

• A
  Protocols of HDAC1 activator treatment and behavioral tests. WT or FTLD‐TDP Tg mice (6‐mon‐old) were i.p. injected with HDAC1 activator 5104434 for 2 months (6 mg/kg/day), following which they were subjected to a series of behavioral tests and then sacrificed for further examination.
• B
  Escape latency of mice in Morris water maze task. *WT+Vehicle mice versus Tg+Vehicle mice, ^#Tg+5104434 mice versus Tg+Vehicle mice. Statistical analysis by two‐way ANOVA with Bonferroni's multiple comparisons. ^# P < 0.05, ***P ≤ 0.001 and ****^/#### P ≤ 0.0001, exact P values are shown in Appendix Table S1.
• C
  The representative searching path of mice in the probe test.
• D
  Scores of mice with respect to the number of times they crossed the hidden platform, time spent searching in the target quadrant, and the velocity of swimming in the probe test at 24 h after escape training. **P = 0.009, ***P = 0.0002 by multiple comparison.
• E
  Scores of the discrimination index in the novel object recognition test.
• F
  Scores of mice in the rotarod test.

Data information: N = 12 mice per group for (B, D‐F). All data are presented as mean ± SEM, ****P < 0.0001 by multiple comparison.