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. 2020 Apr 30;12(6):e11248. doi: 10.15252/emmm.201911248

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© 2020 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure EV3 — A–L
Ensemble optimization method (EOM) fit (green) to scattering data from Fig 3H of PICK1 in complex with Tat‐P₄‐(C5)₂ (2 mg/ml) (blue) using a pool (10,000 structures) with R_g and D_max distribution shown below for (A‐C) dimeric PICK1, (D‐F) a circularly configuration of tetrameric PICK1, (G‐I) an offset configuration of tetrameric PICK1, and (J‐L) a side‐by‐side circularly configuration of tetrameric PICK1. The side‐by‐side configuration provided the best fit as indicated by the lowest χ²‐value.