Table 4.
Histopathological lesion scores of the lung and spleen in different experimental groups.
| Organs | Descriptive Lesions | Control | S. Lappa | TA | Co-Treated | Prophylactic |
|---|---|---|---|---|---|---|
| Spleen | Thickening in the wall of center arterioles | − | − | +++ | − | − |
| Congestion of red pulp with inflammatory cells infiltration | − | − | +++ | + | − | |
| Depletion of lymphocytes inside white pulp | − | − | +++ | − | − | |
| Hyperplasia of white pulp | − | − | − | + | ++ | |
| Splenic CD8+ | ++++ (51%–75%) |
++++ (51%–75%) |
+ (<10%) |
++ (10%–25%) |
+++ (26%–50%) |
|
| Lung | Pulmonary edema | − | − | +++ | − | − |
| Thickening of interalvealar septa | − | − | +++ | + | − | |
| A focal area of necrosis | − | − | +++ | − | − | |
| Aggregation of lymphocytes to form lymphoid follicles | − | − | − | + | ++ | |
| Lung Caspase-3 | + (<10%) |
+ (<10%) |
++++ (51%–75%) |
+++ (26%–50%) |
++ (10%–25%) |
Lesions were scored for severity (− absent, + mild, ++ moderate, +++ severe). Saussurea lappa (S. lappa), triamcinolone acetonide (TA).