Table 3.
Plasma kinetic parameters for EGCG after the three preparations.
| Parameters | G | Teavigo® | Teavigo® with Breakfast | FontUp® |
|---|---|---|---|---|
| AUC0–360 (μg/mL/kg/6 h) |
♂ ♀ |
3.9 ± 4.1 3.3 ± 1.1 |
1.5 ± 0.6 2.4 ± 1.1 |
0.6 ± 0.1 ** 0.8 ± 0.2 ** |
| Cmax (ng/mL/kg) | ♂ ♀ |
5.9 ± 4.1 6.7 ± 1.7 |
3.9 ± 1.3 4.5 ± 2.1 |
0.9 ± 0.1 ** 1.3 ± 0.3 ** |
| Cav (ng/mL/kg) | ♂ ♀ |
3.0 ± 2.6 3.7 ± 2.3 |
1.5 ± 1.5 2.1 ± 2.0 |
0.6 ± 0.2 ** 0.9 ± 0.4 ** |
| Cmin (ng/mL/kg) | ♂ ♀ |
1.5 ± 1.4 2.2 ± 1.1 |
0.7 ± 0.4 2.2 ± 1.6 |
0.3 ± 0.1 * 0.3 ± 0.0 * |
| T1/2 (min) | ♂ ♀ |
154.2 ± 27.9 117.2 ± 53.5 |
93.1 ± 36.2 * 111.4 ± 39.1 |
191.7 ± 66.4 132.9 ± 27.9 |
| Tmax (min) | ♂ ♀ |
120 (90–180) 90 (60–120) |
120 (90–180) 180 (120–360) |
90 (60–90) 120 (90–120) |
Values are means ± standard deviations for the 10 participants (n = 10), except for Tmax (median with the minimum and maximum time observed). * Value is significantly different from the other values in the row at the level of p < 0.05. ** Value is significantly different from the other values in the row at the level of p < 0.001. Abbreviations: G = gender; min = minutes; h = hours; ♂ = man; ♀ = women; AUC0–360 = area under the curve from 0 to 6 h; Cmax = maximum concentration; Cav = average concentration; Cmin = minimum concentration (at the end of the treatment); T1/2 = half-life; Tmax = time required to reach the maximal concentration.