Table 2.
Taurisolo reprograms metabolism of mice livers.
| Metabolite | Taurisolo 800 mg/L | Metabolite | Taurisolo 800 mg/L |
|---|---|---|---|
| TMAO | 0.3 ± 0.1 *** | Cholesterol | 0.7 ± 0.1 ** |
| Glucose | 2.3 ± 0.3 *** | Squalene | 0.8 ± 0.1 * |
| Glucose 6-P | 1.3 ± 0.1 * | Farnesyl-2,6-PP | 0.5 ± 0.2 ** |
| Fructose-1,6-PP | 1.1 ± 0.2 n.s. | Linoleate | 1.3 ± 0.1 ** |
| 6-P-Gluconate | 1.5 ± 0.2 * | Stearate | 1.2 ± 0.1 * |
| Ribulose-1,5-PP | 1.2 ± 0.2 n.s. | Oleate | 1.4 ± 0.2 ** |
| Ribose-5-P | 1.1 ± 0.2 n.s. | Palmitate | 1.5 ± 0.1 ** |
| Sedoheptulose | 1.1 ± 0.2 n.s. | Palmitoleate | 1.4 ± 0.2 ** |
| Sedoheptulose-1,7-PP | 1.1 ± 0.3 n.s. | Pentadecanoate | 1.4 ± 0.1 ** |
| Sedoheptulose-7-P | 1.1 ± 0.1 n.s. | Cholic acid | 0.5 ± 0.1 *** |
| Acetyl-CoA | 1.4 ± 0.2 * | Deoxycholic acid | 0.6 ± 0.1 *** |
| UDP-Glucose | 1.7 ± 0.3 ** | Taurocholic acid | 0.5 ± 0.1 *** |
| Maltose | 1.6 ± 0.1 ** | Glutamate | 0.6 ± 0.1 *** |
| Malate | 2.3 ± 0.3 *** | Glutamine | 0.4 ± 0.1 *** |
| Citrate | 1.5 ± 0.2 *** | Arginine | 0.6 ± 0.2 ** |
| Succinate | 1.3 ± 0.1 ** | Ornithine | 1.3 ± 0.2 ** |
| ATP | 1.5 ± 0.3 ** | Citrulline | 1.0 ± 0.1 n.s. |
| ADP | 2.1 ± 0.3 *** | Aspartate | 1.0 ± 0.2 n.s. |
| AMP | 1.3 ± 0.1 * | Taurine | 2.2 ± 0.3 *** |
| Glycerol1-P | 1.6 ± 0.1 ** | GSH | 1.9 ± 0.3 *** |
Fold change (over PLACEBO) measured for the indicated metabolites in liver-fed HFD and receiving 123 mg/kg/die of Taurisolo. Metabolites were extracted from mice liver and analyzed by Mass Spectrometry as described in the methods section. 1 (n = 12. Shown is mean ± s.e.m.) *** = p < 0.001; ** = p < 0.01; * = p < 0.05; n.s. non-statistically different from PLACEBO.