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. 2020 May 8;9(5):397. doi: 10.3390/antiox9050397

Figure 1.

Figure 1

Evaluation of the antioxidant potential of eicosapentaenoic (EPA)-derived FAHFAs in C3A cells. (A) Cell viabilities (IC50) of 12-EPAHSA and 12-EPAHOA (B) Reporter gene assay results of 12-EPAHSA and 12-EPAHOA (C) Relative nuclear Nrf2 protein expression induced by 12-EPAHSA (D) Protein levels of Nrf2 by Western blot analysis after treated with 12-EPAHSA. (E) Relative expression of antioxidant enzymes in response to 12-EPAHSA treatment. * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant (one-way ANOVA) (n = 6). (NQO1: NAD(P)H quinone oxidoreductase 1, HO1: heme oxygenase-1, GCLM: glutamate–cysteine ligase modulatory subunit, GCLC: glutamate–cysteine ligase catalytic subunit, CAT: catalase, and SOD1: superoxide dismutase 1).