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A schematic presentation of interactions between nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NF-κB) transcription factors. Under stressed conditions, Nrf2 translocates to the nucleus and activates the Nrf2/antioxidant responsive element (ARE) signaling pathway, which assists in the downstream regulation of NF-κB activity and expression of inflammatory genes.
