Table 3.
Compound | TNF-α | IL-6 |
---|---|---|
Silybin A | 29.9 ± 1.35 c | 8.4 ± 0.3 d |
Silybin B | 53.3 ± 0.7 f | 5.2 ± 0.2 b |
Silybin AB | 38.7 ± 0.0 d | 4.8 ± 0.3 a,b |
Dehydrosilybin A | 20.7 ± 0.4 a | 4.2 ± 0.2 a |
Dehydrosilybin B | 44.2 ± 0.3 e | 7.0 ± 0.1 c |
Dehydrosilybin AB | 26.7 ± 0.1 b | 15.4 ± 0.6 e |
Data represent the average of concentrations necessary to halve the release of TNF-α and IL-6 (IC50, µM) of three repetitions with corresponding standard errors of the mean. The data were analyzed with one-way analysis of variance (ANOVA, Statistica software (Tibco Software Inc., Tulsa, OK, USA)) and Duncan’s post hoc test, where the differences between groups were considered statistically significant when p < 0.05. Statistical significances are denoted by different letters.