Table A2.
Effect of silybin and dehydrosilybin isomers combined with doxorubicin at IC25 on expression of ABC (ATP-binding cassette) superfamily genes in doxorubicin-resistant ovarian carcinoma (A2780/DOX).
| Silybin A | Silybin B | Silybin AB | Dehydrosilybin A | Dehydrosilybin B | Dehydrosilybin AB | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | Expression Difference | p | Treated vs. Untreated | Expression Difference | p | Treated vs. Untreated | Expression Difference | p | Treated vs. Untreated | Expression Difference | p | Treated vs. Untreated | Expression Difference | p | Treated vs. Untreated | Expression Difference | p | Treated vs. Untreated |
| PPI | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | |||||||||||||
| ABCA1 | 2.702 | 0.000 | UP | 2.415 | 0.000 | UP | 2.922 | 0.000 | UP | 4.172 | 0.000 | UP | 4.412 | 0.000 | UP | 3.122 | 0.000 | UP |
| ABCA2 | 1.239 | 0.000 | UP | 0.903 | 0.000 | DOWN | 1.207 | 0.000 | UP | 1.105 | 0.000 | UP | 1.078 | 0.000 | UP | 1.046 | 0.000 | UP |
| ABCA3 | 0.794 | 0.000 | DOWN | 1.142 | 0.064 | 1.042 | 0.455 | 1.060 | 0.116 | 0.943 | 0.061 | |||||||
| ABCA5 | 2.427 | 0.000 | UP | 1.821 | 0.000 | UP | 2.122 | 0.000 | UP | 1.223 | 0.000 | UP | 1.707 | 0.000 | UP | 1.254 | 0.000 | UP |
| ABCB2 | 17.975 | 0.000 | UP | 15.698 | 0.000 | UP | 18.114 | 0.000 | UP | 5.557 | 0.000 | UP | 9.286 | 0.000 | UP | 5.145 | 0.000 | UP |
| ABCB6 | 1.665 | 0.000 | UP | 1.527 | 0.000 | UP | 1.149 | 0.059 | 1.343 | 0.059 | 1.262 | 0.061 | ||||||
| ABCB9 | 1.586 | 0.000 | UP | 1.241 | 0.000 | UP | 1.638 | 0.000 | UP | 1.109 | 0.059 | 1.218 | 0.000 | UP | 1.149 | 0.061 | ||
| ABCB10 | 1.060 | 0.032 | UP | 0.835 | 0.000 | DOWN | 1.069 | 0.039 | UP | 1.020 | 0.040 | UP | 1.221 | 0.035 | UP | 1.119 | 0.025 | UP |
| ABCC1 | 1.711 | 0.000 | UP | 1.640 | 0.000 | UP | 0.907 | 0.388 | 1.213 | 0.059 | 1.301 | 0.061 | ||||||
| ABCC5 | 1.782 | 0.000 | UP | 1.473 | 0.000 | UP | 1.787 | 0.000 | UP | 1.116 | 0.397 | 1.385 | 0.059 | 1.288 | 0.061 | |||
| ABCC10 | 1.812 | 0.032 | UP | 1.349 | 0.036 | UP | 1.855 | 0.039 | UP | 1.214 | 0.040 | UP | 1.618 | 0.035 | UP | 1.323 | 0.025 | UP |
| ABCD1 | 2.868 | 0.064 | 1.435 | 0.067 | 1.784 | 0.056 | 1.412 | 0.042 | UP | |||||||||
| ABCD2 | 0.426 | 0.000 | DOWN | 0.448 | 0.000 | DOWN | 0.494 | 0.000 | DOWN | 0.698 | 0.000 | DOWN | 0.733 | 0.000 | DOWN | 0.712 | 0.000 | DOWN |
| ABCD3 | 1.637 | 0.000 | UP | 1.560 | 0.000 | UP | 1.043 | 0.397 | 1.347 | 0.000 | UP | 1.288 | 0.000 | UP | ||||
| ABCF1 | 0.137 | 0.000 | DOWN | 0.920 | 0.397 | 0.784 | 0.059 | 0.923 | 0.400 | |||||||||
| ABCF2 | 1.242 | 0.032 | UP | 1.463 | 0.039 | UP | 1.044 | 0.113 | 1.226 | 0.035 | UP | 1.343 | 0.025 | UP | ||||
| ABCF3 | 1.570 | 0.000 | UP | 1.335 | 0.000 | UP | 1.554 | 0.000 | UP | 1.096 | 0.059 | 1.963 | 0.000 | UP | 1.326 | 0.000 | UP | |
| ABCG1 | 1.559 | 0.073 | 2.714 | 0.000 | UP | 2.931 | 0.000 | UP | 1.826 | 0.056 | ||||||||
| ABCG2 | 2.415 | 0.000 | UP | 1.902 | 0.000 | UP | 2.373 | 0.000 | UP | 1.259 | 0.073 | 1.948 | 0.000 | UP | 1.698 | 0.000 | UP | |
| ABCG4 | 4.751 | 0.000 | UP | 4.110 | 0.000 | UP | 5.289 | 0.000 | UP | 1.992 | 0.000 | UP | 2.860 | 0.000 | UP | 2.008 | 0.000 | UP |