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NAD+ regulates oxytocin activity via CD38 and cADPR. Social behaviour is regulated by the amount of central OXT released due to NAD-dependent calcium release by CD38 activity and cADPR generation. Abbreviations: NAD+, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate; CD38, NAD+ glycohydrolase; cADPR, cyclic adenosine diphosphoribose; OXT, oxytocin; NAADP, nicotinic acid adenine dinucleotide phosphate; Ryr, ryanodine receptor.
