Table 5.

Modulation of resistance to doxorubicin by lemongrass essential oil. The table shows the concentrations of doxorubicin that halved the viability of human ovarian carcinoma (HOC) cell lines in the presence of lemongrass essential oil and doxorubicin with a single-dose addition of lemongrass essential oil (10 µL/L). Both HOC and the same line resistant to doxorubicin (HOC/DOX) were tested.

	HOC	HOC/DOX
Doxorubicin, IC50 [µM]	0.022 ± 0.001	2.86 ± 0.18
Lemongrass, IC50 [µL/L]	55.2 ± 8.1	197.8 ± 5.7
Doxorubicin, IC50 [µM] with lemongrass essential oil [10 µL/L]		1.60 ± 0.14
Sensitization FOLD		1.78 ± 0.27

The sensitization factor was calculated as the ratio of IC₅₀ [doxorubicin, µM] and IC₅₀ [doxorubicin in the presence of lemongrass essential oil, µM]. The data are presented as an average of 3 repetitions with SE.