Table 2. Changes of hemodynamics and respiratory mechanics (N = 32).
All data are expressed as means ± SD.
| Parameters | Groups | TLV15min | OLV30min | OLV60min | ReTLV | P value |
|---|---|---|---|---|---|---|
| PaO2(mmHg) | 0.000b | |||||
| Placebo | 431.8 ± 54.3 | 168.6 ± 43.6 | 178.5 ± 41.3 | 402.1 ± 42.1 | 0.000 | |
| Dex0.5 | 435.8 ± 44.1 | 217.9 ± 43.5* | 255.6 ± 47.0* | 418.7 ± 33.2 | 0.000 | |
| Dex1 | 424.5 ± 38.7 | 242.5 ± 60.8* | 282.1 ± 54.6* | 405.8 ± 37.8 | 0.000 | |
| Dex2 | 423.4 ± 53.3 | 262.7 ± 53.6* | 298.6 ± 38.4* | 409.1 ± 51.6 | 0.000 | |
| P value | 0.691 | 0.000 | 0.000 | 0.429 | 0.000a(P = 0.000c) | |
| Cdyn (ml/cmH2O) | 0.000b | |||||
| Placebo | 43.4 ± 7.1 | 21.0 ± 2.8 | 19.7 ± 2.8 | 32.4 ± 2.7 | 0.000 | |
| Dex0.5 | 42.8 ± 6.0 | 26.7 ± 2.4* | 26.2 ± 2.4* | 38.7 ± 2.6* | 0.000 | |
| Dex1 | 42.2 ± 5.3 | 26.4 ± 2.6* | 25.5 ± 2.6* | 37.8 ± 1.8* | 0.000 | |
| Dex2 | 41.5 ± 4.3 | 26.9 ± 3.2* | 26.2 ± 2.9* | 38.5 ± 2.5* | 0.000 | |
| P value | 0.619 | 0.000 | 0.000 | 0.000 | 0.000a(P = 0.000c) | |
| Qs/Qt (%) | 0.000b | |||||
| Placebo | 9.9 ± 2.2 | 30.4 ± 2.3 | 27.5 ± 1.4 | 9.5 ± 0.5 | 0.000 | |
| Dex0.5 | 9.8 ± 1.2 | 30.0 ± 3.0 | 27.2 ± 2.5 | 9.4 ± 0.7 | 0.000 | |
| Dex1 | 9.4 ± 2.0 | 24.6 ± 2.2* | 22.3 ± 3.6* | 9.4 ± 0.6 | 0.000 | |
| Dex2 | 9.7 ± 2.3 | 22.6 ± 2.5* | 21.6 ± 3.1* | 9.8 ± 0.6 | 0.000 | |
| P value | 0.789 | 0.000 | 0.000 | 0.112 | 0.000a(P = 0.000c) | |
| HR (bpm) | 0.000b | |||||
| Placebo | 68.9 ± 9.3 | 74.6 ± 11.4 | 76.0 ± 10.3 | 79.3 ± 10.9 | 0.002 | |
| Dex0.5 | 70.4 ± 11.9 | 73.6 ± 13.2 | 72.8 ± 12.3 | 74.3 ± 13.1 | 0.640 | |
| Dex1 | 72.1 ± 10.3 | 71.6 ± 11.0 | 71.0 ± 11.5 | 74.9 ± 9.7 | 0.478 | |
| Dex2 | 68.3 ± 8.4 | 73.0 ± 10.0 | 70.3 ± 8.0 | 72.6 ± 9.0 | 0.121 | |
| P value | 0.424 | 0.772 | 0.143 | 0.086 | 0.397a(P = 0.064c) | |
| MAP (mmHg) | 0.000b | |||||
| Placebo | 82.0 ± 8.2 | 84.1 ± 9.5 | 83.0 ± 9.2 | 92.0 ± 10.2 | 0.000 | |
| Dex0.5 | 83.3 ± 10.6 | 81.5 ± 9.8 | 84.4 ± 8.7 | 88.3 ± 9.3 | 0.043 | |
| Dex1 | 85.6 ± 18.1 | 84.2 ± 8.5 | 83.6 ± 9.3 | 90.0 ± 9.1 | 0.132 | |
| Dex2 | 84.7 ± 6.8 | 82.2 ± 11.0 | 83.0 ± 9.3 | 90.7 ± 10.8 | 0.002 | |
| P value | 0.633 | 0.611 | 0.914 | 0.502 | 0.863a(P = 0.580c) | |
| BIS | 0.000b | |||||
| Placebo | 45.6 ± 2.9 | 43.5 ± 2.2 | 44.1 ± 2.0 | 47.5 ± 2.0 | 0.000 | |
| Dex0.5 | 45.4 ± 2.4 | 43.2 ± 2.4 | 43.9 ± 2.3 | 47.2 ± 1.3 | 0.000 | |
| Dex1 | 45.6 ± 2.9 | 43.0 ± 2.4 | 44.8 ± 2.0 | 47.6 ± 2.0 | 0.000 | |
| Dex2 | 45.3 ± 2.8 | 42.9 ± 2.2 | 44.9 ± 2.3 | 47.8 ± 2.5 | 0.000 | |
| P value | 0.974 | 0.727 | 0.171 | 0.759 | 0.815a(P = 0.650c) |
Notes.
Compared with Placebo group.
*
P < 0.05.
a
P value of main effect(group).
b
P value of main effect(time).
c
P value of crossover effect.