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. 2020 May 15;21(10):3516. doi: 10.3390/ijms21103516

Figure 5.

Figure 5

Comparison of subepithelial nerve density and presumed dendritic cell density measured by in vivo confocal microscopy. (A) Representative confocal microscopy image showed marked decrease of subepithelial nerve in the EDES+/Treatment− group. (B) Representative confocal microscopy image showed marked increase of subepithelial dendritic cell infiltration in the EDES+/Treatment− group. (C) The mean subepithelial nerve density in the EDES+/Treatment− group was significantly lower than other groups. (D) The mean subepithelial dendritic cell density in the HMWHA and EDES−/Treatment− groups was significantly lower than the EDES+/Treatment− group. * and ** represent p < 0.05 and p < 0.001 when each group was compared with the EDES+/Treatment− group, respectively. Scale bar shows 100 µm. Black arrowheads show presumed dendritic cells. LMWHA, low molecular weight hyaluronic acid (HA); DQ, diquafosol sodium; HMWHA, high molecular weight HA; EDES, environmental dry eye stress.