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. 2020 May 17;21(10):3546. doi: 10.3390/ijms21103546

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustration of the novel regulatory mechanism for p38α through arginine methylation on R49/R149 by PRMT1. AraC treatment stimulates the methyltransferase activity of PRMT1, which methylates p38α on R49 and R149. This facilitates the interaction of p38α and MKK3 and enhances the activation phosphorylation of p38α by MKK3. The interaction of p38α with downstream effector MAPKAPK2 is also increased upon R49/R149 methylation by PRMT1 methylation. Together, erythroid differentiation is promoted due to the facilitated p38α signaling. Green arrow: methylation. Yellow arrow: phosphorylation.