3D	three-dimensional
ANXA10	AnnexinA10
CD	Crohn’s disease
DEGs	Differentially expressed genes
G2019S	Gly2019Ser substitution
GBA	Glucocerebrosidase
GI	Gastrointestinal
GS mIOs	Human LRRK2 G2019S mutant mouse small intestinal organoids
GWAS	Genome-wide association studies
hIOs	Human intestinal organoids
hNESs	Human neuroectodermal spheres
IOs	Intestinal organoids
iPSCs	Induced pluripotent stem cells
IRX2	Iroquois homeobox protein 2
LMO3	LIM domain only protein 3
LRRK2	Leucine-rich repeat kinase 2
MAP2	Microtubule-associated protein 2
mIOs	Mouse small intestinal organoids
NESs	Neuroectodermal spheres
PD	Parkinson’s disease
PSC	Pluripotent stem cells
SN	Substantia nigra
SNCA	Alpha-synuclein
SNPs	Single nucleotide polymorphisms
TFF2	Trefoil factor 2
TG	Transgenic
TH	Tyrosine hydroxylase
TRAM	Transcriptome Mapper
UC	Ulcerative colitis
WT mIOs	Non-transgenic littermate mouse small intestinal organoids