Table 1.

PHLD Class Proteins and Cancer.

	Expression Level in Normal Tissues *	Expression Level in Disease	References
PHLDA1	All Tissues ↑ Salivary Glands	↓ Breast Cancer	[7,11,12,15]
		↓ Ovarian Cancer	[7,11]
		↓ Endometrial Cancer	[7,12]
		↓ Lung Cancer	[15]
		↓ Gastric Cancer	[7,16]
		↑ Colorectal Cancer	[7,17]
		↑ Osteosarcoma	[7,8]
PHLDA2	Many Tissues ↑ Placenta	↓ Breast Cancer	[14]
		↓ Lung Cancer	[14]
		↓ Osteosarcoma	[18]
PHLDA3	All Tissues	↓ Lung Cancer (Neuroendocrine Tumor)	[13]
		↓ Pancreatic Cancer (Neuroendocrine Tumor)	[19,20]
PHLDB1	Many Tissues ↑ Brain	SNPs ↑ Brain Cancer	[21,22]
PHLDB2	Many Tissues ↑ Placenta	↑ Colorectal Cancer	[23]
PHLDB3	All Tissues	↑ Colorectal Cancer	[24]

* RNA expression cited from the Human Protein Atlas (proteinatlas.org).