Figure 2.

Histopathological analysis of treated and untreated wounds at D3. (A) Five-μm sections stained by hematoxylin and eosin (HE) showing copaiba-treated wounds with predominance of granulation tissue, whereas acute inflammatory cells (neutrophils) predominated in most wounds from the corticoid and control groups. (B) Copaiba-treated wounds presented a significantly higher score of the inflammatory stage, which indicates a decreased acute inflammatory reaction and (C) a more advanced stage of reepithelization. The corticoid-treated wounds showed lower scores of reepithelization at D3, demonstrating poor tissue repair (original magnification ×200 and ×1000). One-way ANOVA and Tukey’s post hoc tests (n = 15) (* p < 0.05).