Figure 1.
TRM cells demonstrate expression of CD49a, CD69 and CD103 particles. Due to the stimulation of IL-15, they secreting perforin, granzyme B and IFN-γ, indicating in this way a cytotoxic effect on melanocytes. Additionally, TRM produce chemokines CXCL9 and CXCL10, which, after binding with receptor CXCR3 on the surface of TRCM cells, influence their recruitment from the blood vessels to the skin. Next, through the synergistic effect, they cause the depigmentation of the skin in the course of disease.